Frank Müller, Institute of Structural Biology and Biophysics, Cellular Biophysics (ISB-1) and University of Aachen

Molecular sensory physiology and neurobiology. Cellular signalling in sensory cells and neurons. Biophysics of ion channels and membrane receptors. Information processing in the retina. Electrophysiology and anatomy of the retina of normal and genetically modified animals. Various spectroscopic techniques to study the dynamics of protein function and kinetics of second messenger responses.

Selected Publications

Gotzes, S., de Vente, J. und Müller, F. (1998): Nitric oxide modulates cGMP levels in neurons of the inner and outer retina in opposite ways. Visual Neuroscience 15:945-955.

Müller, F., Bönigk, W., Sesti, F. und Frings, S. (1998): Phosphorylation within a regulatory domain of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity. Journal of Neuroscience 18:164-173.

Körschen, H.G., Beyermann, M., Müller, F., Heck, M., Vantler, M., Koch, K.W., Kellner, R., Wolfrum, U., Bode, C., Hofmann, K.P. und Kaupp, U.B. (1999): Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors. Nature 400:761-766.

Müller, F., Vantler, M., Weitz, D., Eismann, E., Zoche, M., Koch, K.W. und Kaupp, U.B. (2001): Ligand sensitivity of the α2 subunit from bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin. Journal of Physiology 532: 399-409.

Stevens, D.R., Seifert, R., Bufe, B., Müller, F., Kremmer, E., Gauss, R., Meyerhof, W., Kaupp, U.B. und Lindemann, B. (2001): The hyperpolarization-activated channels HCN1 and 4 mediate reponses to sour stimuli. Nature 413(6856):631-635.

Müller, F., Scholten, A., Ivanova, E., Haverkamp, S., Kremmer, E., und Kaupp, U.B. (2003): HCN channels are differentially expressed in retinal bipolar cells and concentrated at synaptic terminals. European Journal of Neuroscience 17: 2084-2096.

Ivanova, E. und Müller, F. (2006): Retinal bipolar cells differ in their inventory of ion channels. Visual Neuroscience 23: 143-154.

Mataruga, A., Kremmer, E. und Müller, F. (2007): Type 3a and 3b OFF-cone bipolar cells provide for the alternative rod pathway in the mouse retina. Journal of Comparative Neurology 502: 1123-1137.

Knop, G., Seeliger, M.W., Thiel, F., Mataruga, A., Kaupp, U.B., Friedburg, C., Tanimoto, N, und Müller, F. (2008): Light responses in the mouse retina are prolonged upon targeted deletion of the HCN1 channel gene. European Journal of Neurosience 28:2221-2230