Dr. G. Schröder

G. F. Schröder,
Forschungszentrum Jülich, Structural Biochemistry

A major challenge in structural biology is to determine the structure and dynamics of large protein complexes and other biomolecular assemblies. We are developing computational tools to build and refine atomic models of protein using low-resolution data mostly from X-ray crystallography and single-particle cyro-EM. In particular we are combining of data analysis and protein structure prediction methods.

Selected Publications

T. Sabir, G.F. Schröder, A. Toulmin, P. McGlynn, and S.W. Magennis. Global Structure of Forked DNA in Solution Revealed by High-Resolution Single-Molecule Fluorescence Resonance Energy Transfer. JACS , DOI: 10.1021/ja108626w.

V.E. Galkin, A. Orlova, G.F. Schröder, E.H. Egelman. Structural Polymorphism in F-actin. Nat Struct Mol Biol (2010) 17:1318-1323.

G.F. Schröder, M. Levitt, A.T. Brunger. Super-resolution biomolecular crystallograph y with low-resolution data. Nature (2010) 464:1218-1222.

J. Zhang, M.L. Baker, G.F. Schröder, N.R. Douglas, S. Reissmann, J. Jakana, M. Dough erty, C.J. Fu, M. Levitt, S.J. Ludtke, J. Frydman, and W. Chiu. Mechanism of folding chamber closure in a group II chaperonin. Nature (2010) 463:379-383.

A. K. Wozniak, G.F. Schröder, H. Grubmüller, C.A.M. Seidel, F. Oesterhelt. Single mo lecule FRET measures bends and kinks in DNA. PNAS (2008) 105(47):18337-18342.

O.F. Lange, N.-A. Lakomek, C. Fares, G.F. Schröder, S. Becker, J. Meiler, H. Grubmüller, C. Griesinger, B.L. de Groot. Atomistic residual dipolar coupling ensemble of u biquitin reveals molecular recognition dynamics up to the microsecond timescale. Sci ence (2008) 320:1471-1475.

G.F. Schröder, A.T. Brunger, and M. Levitt. Combining Efficient Conformational Sampling with a Deformable Elastic Network Model Facilitates Structure Refinement at Low Resolution. Structure (2007) 15:1630-1641.

G. F. Schröder, U. Alexiev, and H. Grubmüller. Simulation of fluorescence anisotropy experiments Probing protein flexibility. Biophys. J. (2005) 89:3757-3770.

A. Wozniak, S. Nottrott, E. Kühn-Hölsken, G. F. Schröder, H. Grubmüller, R. Lührmann, A. M. Seidel and F. Oesterhelt. Detecting protein-induced folding of the U4 snRNA kinkturn by single-molecule multiparameter FRET measurements. RNA (2005) 11:1545-155 4.

M. Margittai, J. Widengren, E. Schweinberger, G.F. Schröder, S. Felekyan, E. Haustein, M. König, D. Fasshauer, H. Grubmüller, R. Jahn, and C. A. M. Seidel. Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of Syntaxin 1. PNAS (2003) 100(26):15516-15521.

G.F. Schröder and H. Grubmüller. Maximum likelihood trajectories from single molecule fluorescence resonance energy transfer experiments. J. Chem. Phys. (2003) 119(18):9920-9924.

G.F. Schröder and H. Grubmüller. FRETsg : Biomolecular structure model building from multiple FRET experiments. Comp. Phys. Comm. (2003) 158:150-157.