C. Seidel, Institut für Physikalische Chemie, University of Düsseldorf.
A large variety of different experimental techniques, such as multi-dimensional confocal fluorescence spectroscopy, atomic force microscopy, and fluorescence correlation spectroscopy, are employed to investigate molecular biocatalysts, and the interplay of molecular conformations and biological function of single molecules.
Prof. Dr. Claus Seidel
| 1980-1983 | Study of Chemistry at the University of Stuttgart |
| 1983-1988 | Study of Chemistry at the University of Heidelberg |
| 1988-1992 | Ph.D. in Physical Chemistry at the University of Heidelberg |
| 1998 | Habilitation and Priv. Doz. for Physical Chemistry at the University of Heidelberg |
| 1998 | BioFuture Research Prize |
| 2002 | Professor for Physical Chemistry at the Heinrich-Heine-University of Düsseldorf |
P. Rothwell, S. Berger, O. Kensch, S. Felekyan, M. Antonik, T. Restle, B. Wöhrl, R. Goody, C.A.M. Seidel, (2003). Multi-parameter Single-molecule Fluorescence Spectroscopy reveals Heterogeneity of HIV-1 Reverse Transcriptase:primer/template Complexes. Proc. Natl. Acad. Sci. USA. 100, 1655-1660.
M. Margittai, E. Schweinberger, J. Widengren, D. Fasshauer, G. Schroder, E. Haustein, S. Felekyan, M. König, H. Grubmüller, R. Jahn, C.A.M. Seidel (2003). Single molecule FRET dynamics reveals an equilibrium between a closed and an open conformation of syntaxin. Proc. Natl. Acad. Sci. USA. 100, 15516-15521.
M. Diez, B. Zimmermann, M. Börsch, M. König, E. Schweinberger, S. Steigmiller, R. Reuter, S. Felekyan, V. Kudryavtsev, C.A.M. Seidel, P. Gräber (2004). Proton-powered subunit rotation in single membrane-bound F0F1-ATP synthase. Nat. Struct. Mol. Biol. 11, 135-141.
A. Gaiduk, R. Kühnemuth, M. Antonik, C.A.M. Seidel (2005). Optical characteristics of AFM tips for single molecule fluorescence applications. ChemPhysChem. 6, 976-983.
W. Al-Soufi, B. Reija, M. Novo, S. Felekyan, R. Kühnemuth, C.A.M. Seidel (2005). Fluorescence correlation spectroscopy, a tool to investigate supramolecular dynamics: Inclusion complexes of pyronines with cyclodextrines. J. Am. Chem. Soc. 127, 8775-8784.
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