B. Strodel
Forschungszentrum Jülich, Structural Biochemistry

Development of multiscale methods that bridge from the atomistic (microscopic) to a coarser (mesocopic) level for the description of biomolecules. Simulations investigating biomolecular self-assembly in proteins. Investigation of the protein-protein interactions driving protein aggregation. Specific projects are: Alzheimer's Aβ peptide interacting with lipid bilayers, D-peptides for the therapy of Alzheimer's disease, coarse-grained simulations of amyloid aggregation, development of a protein-protein docking program.

Jun.-Prof. Birgit Strodel

Jun.-Prof. Birgit Strodel

2009Junior Group Leader in 'Computational Biology' at the Institute of Structural Biochemistry (ICS-6), Forschungszentrum Jülich
2006-2008Postdoc at the Chemistry Department, University of Cambridge, UK
2001-2005Ph.D. at the Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt/Main
2000Diploma work in Chemistry at the Institute of Theoretical Chemistry, Heinrich-Heine University Düsseldorf
1995 – 2000Undegraduate studies in Chemistry at the Heinrich-Heine University Düsseldorf and the University of North Carolina, Chapel Hillf

Selected Publications

Modelling Proteins: Conformational Sampling and Reconstruction of Folding Kinetics K. Klenin, B. Strodel, D.J. Wales and W. Wenzel, BBA-Proteins and Proteomics, DOI:10.1016/j.bbapap.2010.09.006 (2011)

Transmembrane structures for Alzheimer's Aβ(1-42) oligomers. B. Strodel, J.W.L. Lee, C.S. Whittleston and D.J. Wales, J. Am. Chem. Soc. 132: 13300–13312 (2010).

Frontiers Article: Free Energy Surfaces from an Extended Harmonic Superposition Approach and Kinetics for Alanine Dipeptide. B. Strodel and D.J. Wales, Chem. Phys. Lett. 466: 105–115 (2008).

Characterizing the first steps of amyloid formation for the ccβ peptide. B. Strodel, A.W. Fitzpatrick, M. Vendruscolo, C.M. Dobson, and D.J. Wales, J. Phys. Chem. B 112: 9998–10004 (2008).

Implicit solvent models and the energy landscape for aggregation of the amyloidogenic KFFE peptide. B. Strodel and D.J. Wales, J. Chem. Theo. Comp. 4: 657–672 (2008).

Thermodynamics and Kinetics of Aggregation for the GNNQQNY Peptide. B. Strodel, C.S. Whittleston, and D.J. Wales, J. Am. Chem. Soc. 129: 16005–16014 (2007).